摘要
15－甲基PGF2α甲酯（PG05）对小鼠有明显的抗早孕作用。（＋）PGOS为有活性的立体异构体，其抗早孕和致腹泻作用均比（±）PGOS强，治疗指数与（±）PG05基本一致。大鼠于妊娠第7、8、9天，皮下注射（±）PG050.5mg／kg有明显的抗早孕作用；同样剂量的PGOS对去卵巢后，靠外源性孕酮和雌酮维持妊娠的大鼠无抗早孕作用。PGOS20μg／ml既可抑制hCG刺激黄体细胞分泌cAMP，又能桔抗SBr－cAMP刺激黄体细胞分泌孕酮，PG05可能在2个或2个以上环节上抑制大鼠卵巢黄体功能。
Treatment with 15-methyl PGF,. methyl ester (PG05) resulted in termination of pregnancy and peristatic effects in mice. (+) PGO5 is the active stereoisomer of racemic PG05.The therapuetic index of (+) PG05 was found to be closely similar to that of (±) PG05.Pregnancy of ovariectomized rats given progesterone and estrone was maintained normally.PG05 was shown to have no effect on the gestation of ovariectomized rats receiving progesterone and estrone injection. PG05 at a concentration of 20μg/ml reduced cAMP secretion ofrat luteal cells in response to hCG in vitro. PG05 at concentration of 10 and 20μg/ml also exerted an inhibitory effect on 8 Br-cAMP-stimulated progesterone production. These resultssuggest that in luteal cells PG05 inhibits steroidogenesis at the steps of gonadotropin-stimulated cAMP formation and cAMP-induced progesterone production.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1994年第3期210-213,共4页
Acta Academiae Medicinae Sinicae
关键词
抗早孕
黄体细胞
黄体酮
PG05
15-methyl PGF_(2α) methyl ester
termination of early pregnancy
luteal cells
progesterone
