摘要
本研究用１０只麻醉犬观察了川芎嗪对急性缺氧性肺动脉高压的影响结果发现，由右心房注射川芎嗪（４０ｍｇ／ｋｇ）能使用药后第１０、１５分钟缺氧时的肺血管阻力（ＰＶＲ）和肺动脉平均压（ＰＡＰｍ）明显降低；若在持续泵入美蓝过程中，川芎嗪的降肺动脉压作用消失，提示美蓝能阻断川芎嗪的扩血管作用。本研究还发现硝酸甘油能快速降低ＰＶＲ及ＰＡＰｍ，提示硝酸甘油可用于治疗急性肺动脉高压及慢性肺原性心脏病急性加重期患者。
The effects of ligustrazine and nitroglycerine on acute hypoxic pulmonary hypertension were observed in 10 anesthetized dogs.The results showed that ligustrazine(40 mg/kg)significantly reduced the hypoxic mean pulmonary artery pressure(PAPm)and pulmonary vascular resistance(PVR)the 10th and 15th minute after its injection into the right atrium,respectively.Its action was blocked by the continuous intravenous injection of methylene blue(1mg/kg/min).It was suggested that the action of ligustrazine could be mediated by endothelium-derived relaxing factor.It was also discovered that nitroglycerine(40μg/kg)could quickly decrease PAPm and PVR, indicating that nitroglycerine can be used to treat acute pulmonary hypertension and the aggravation of chronic cor pulmonale.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1994年第2期79-83,共5页
Acta Academiae Medicinae Sinicae
关键词
川芎嗪
硝酸甘油
美蓝
肺动脉高压
ligustrazine
nitroglycerine
methylene blue
hypoxic pulmonary hypertension
