摘要
目的 探讨妊高症患者血液流变学变化情况,研究血液流变学改变在妊高征发病中的作用。方法 实验组:A组,40例先兆子痫患者;B组,3 8例轻度妊高征患者;和对照组,42例健康孕妇。进行14项血液流变学指标检测。结果 1.实验组高、中、低切全血粘度、血浆粘度、红细胞压积与对照组间差异有显著性(P <0 0 5～0 0 0 1) ;实验组血沉和血沉方程K值与对照组差异无显著性(P >0 0 5 ) ;实验组与对照组纤维蛋白原含量均高于未孕时正常范围,其中B组与对照组间结果差异有显著性(P <0 0 5 )。2 .红细胞变形指数与全血粘度、血浆粘度以及红细胞压积呈负相关(P <0 0 0 1) ;全血粘度与纤维蛋白原含量无相关性(P >0 0 5 )。结论 妊高征患者血液流变学多项指标增高,导致外周血管阻力增加。
Objective To investigate hemorheological status of the peripheral circulation in women with pregnancy-induced hypertension (PIH) and explore the role of hemorheological changes in the pathogenesis of PIH.Methods There were two study groups:group A (40 patients with preeclampsia) and group B (38 patients with light PIH) and one control group (42 normal pregnant women).14 parameters of hemorheology were determined.Results Significant increment(P<0 05～0 001)was found in the states of high,moderate and low shear force of total blood viscosity,plasma viscosity and hematocrit in both study groups compared with control group,but no significant differences were noted in erythrocyte sedimentation rate(ESR) and K titer.Fibrinogen concentration raised in pregnant women,and there was a significant increase between group B and control group (P<0 05).Erythrocyte deformation index had negative relation (P<0 05) with total blood viscosity,plasma viscosity and hematocrit.But there was no significant relation between total blood viscosity and fibrinogen concentration.Conclusions Increase of the peripheral vascular resistance follows with increase of several hemorheological parameters in women with PIH,which is important pathogenesis of PIH.
出处
《浙江预防医学》
2005年第6期6-7,18,共3页
Zhejiang Journal of Preventive Medicine
关键词
妊娠
并发症
高血压
血液流变学
Pregnancy
Complication
Hypertension
Hemorheology
