摘要
目的 观察重组(酵母)乙型肝炎(乙肝)疫苗阻断乙肝病毒(HBV)母婴传播的长期效果,探讨阻断HBV母婴传播的最佳免疫策略。方法 对母亲血清乙肝病毒表面抗原(HBsAg)和乙肝病毒膜抗原(HBeAg)同时阳性、新生儿期全程接种乙肝疫苗后HBsAg阴性的2 73名儿童进行9年血清学追踪观察。结果 共观察到12人HBsAg阳转,1～9岁HBsAg阳性率0 72 %～6 .98% ,低或无应答儿童9岁内17 .78%发生HBsAg阳转;免疫后9年保护性水平乙肝病毒表面抗体(抗 HBs)阳性率仍维持>6. 0 % ;3～5岁加强免疫儿童抗体阳性率及抗体水平高于未加强免疫儿童。结论 重组(酵母)乙肝疫苗对阻断HBV母婴传播具有良好的远期免疫效果。母亲HBsAg和HBeAg双阳性的幼儿在3～4岁时需加强免疫。低或无应答新生儿有较高的HBsAg阳转危险性。
Objective To assess the long-term efficacy of recombinant yeast-derived hepatitis B vaccine in infants born to HBsAg and HBeAg carrier mother. Methods A total of 273 neonates born to HBsAg,HBeAg both positive mothers were vaccinated with 5,5,5 μg doses of recombinant yeast-derived hepatitis B vaccine by 0,1, and 6 months schedule.They were all followed for 1-9 years after the primary vaccination. Results Twelve infants (6.63%) become HBsAg positively conversed in 9 year after primary vaccination,and the positive Rate of HBsAg in 1-9 year was 0.72%-6.8%,17.8% of child in no/lowly-respond become HBsAg positively.At the ninth year the positive rates of anti-HBs were 60% above.Anti-HBs positive rates and immunity level were higher at 3-5 year old by repetition immunity than others. Conclusion The recombinant yeast-derived hepatitis B vaccine have good immunogenecity and long-term protective efficacy to HBV interruption of perinatal transmission,a booster dose seems necessary in aged 3-4 years to the mother with HBsAg and HBeAg.It is high-risk to become HBsAg positively in the baby of norespones to hepatitis B vaccine.
出处
《中国计划免疫》
2005年第2期83-85,共3页
Chinese Journal of Vaccines and Immunization
关键词
重组(酵母)乙型肝炎疫苗
阻断乙型肝炎病毒母婴传播
效果
Recombinant yeast-derived hepatitis B Vaccine
HBV interruption of perinatal transmission
Immunogenicity
