摘要
目的 几乎没有研究报道妊娠高血压综合征(妊高征)患者尿蛋白、孕龄对新生儿出生体重影响的关系,本研究欲探讨各种变化因素对妊高征患者新生儿出生体重影响的量化关系。方法 1997年1月～2 0 0 4年6月期间,在我院住院分娩患中、重度妊高征产妇136例,对新生儿出生体重与各种因素进行单变量和多变量回归分析。结果 单变量回归分析尿蛋白、孕龄分别与新生儿出生体重有高度显著性关系(P <0 .0 0 1) ;尿蛋白和孕龄一起进入多元回归分析,校正影响因素,尿蛋白和孕龄仍然是影响新生儿出生体重显著性因素(P <0 .0 0 1) ,并且每增加一个等级尿蛋白,新生儿出生体重降低2 4 1.92 g (95 %CI :14 4 .77～339.0 7) ;孕龄每增加一天,新生儿出生体重增加2 0 .1g(95 %CI :13.70～2 6 .5 0 )。结论 妊高征患者尿蛋白丢失将严重影响新生儿出生体重,孕龄的延长有增加新生儿出生体重。
Objective: Few studies have examined the effect of mild and severe pregnancy-induced hypertension (PIH) on birth weight according to proteinuria and gestational age. The objective is to study the quantitative relation of the various kinds of factors influencing the birth weight with PIH. Methods: 136 cases with mild and severe PIH were retrospectively analyzed the relation between the various kinds of factors and birth weights performed the way of univariate and multivariable regression during the 1997.1～2004.6. Results: The birth weights was statistically significantly influenced by urinary protein and gestational age in women with mild and severe PIH, respectively (P<0.001). After adjustment for confounding variables, the relation of them still never be changed (P<0.001). Each 1 level protein increase in urine predicted a 241.92g (95%CI: 144.77g～339.07g) decrease in birth weight and each one day increase in gestational age predicted a 20.1g(95%CI: 13.70g～26.50g) increase in birth weight. Conclusion: The loss of urinary protein with PIH patients will severely affect birth weight. The prolonged gestation age will greatly benefit heavier birth weight.
出处
《中国优生与遗传杂志》
2005年第5期62-63,共2页
Chinese Journal of Birth Health & Heredity
关键词
妊娠高血压综合征
新生儿体重
尿蛋白
孕龄
Pregnancy-induced hypertension
Birth weight
Proteinuria
Gestational age
