摘要
目的观察纳洛酮对内毒素血症大鼠肠系膜微循环变化的影响。方法经股静脉注射内毒素5mg kg)建立实验模型,将60只大鼠随机分为对照组、内毒素损伤组和纳络酮干预组,每组20只,分为个亚组,分别观察完成注射后1、2、4、6h微循环变化。结果内毒素损伤后大鼠肠系膜微循环发生显著变化,纳洛酮干预后这种变化明显减轻。内毒素损伤组、纳洛酮干预组大鼠肠系膜微循环的血流速度等指标与对照组有差异。结论纳洛酮可改善内毒素引起的肠系膜微循环障碍。
Objective To investigate the effect of naloxone on mesentery microcirculation in endotoxicemia rats.Methods A rat model of endotoxicemia was established by injection of LPS with a dose of 5mg/kg into thigh vein.sixty SD rats were randomly divided into three groups:control group,endotoxin group,naloxone+endotoxin group.Twenty rats were in each group and were subdivided into 4 subgroups(1 h,2 h,4 h,6 h respectively).In each subgroup,mesentery microcirculation were obserred.Results After injection of endotoxin,mesentery microcirculation changed significantly.Intervention of naloxone relieve those changes.Compared with control group,the other two groups have different signatures such as blood flow rate.Conclusion Naloxone can improve mesentery microcirculation and has protective effect on endotoxicemia rats.
出处
《中华急诊医学杂志》
CAS
CSCD
2005年第5期391-393,共3页
Chinese Journal of Emergency Medicine
