摘要
目的探讨鼻咽癌组织中bcl2、p15的表达水平与预后的关系。方法采用免疫组织化学S P法测定56例鼻咽癌组织中bcl2、p15的表达水平,并分析其与鼻咽原发灶大小、颈淋巴结有无转移、放疗后有无肿瘤残留及与生存期的关系。结果T1-2者bcl2高、低表达分别占68.0%(17/25)、32.0%(8/25),p15分别为20.0%(5/25)、80.0%(20/25),T3-4者bcl2高、低表达分别占77.4%(24/31)、22.6%(7/31),p15分别为38.7%(12/31)、61.3%(19/31);颈淋巴结阳性者bcl2高、低表达分别占69.8%(30/43)、30.2%(13/43),p15分别为37.2%(16/43)、62.8(27/43),颈淋巴结阴性者bcl2高、低表达分别占84.6%(11/13)、15.4%(2/13),p15分别为7.7%(1/13)、92.3%(12/13);放疗后肿瘤残留者bcl2高、低表达分别占74.1%(20/27)、25.9%(7/27),p15分别为33.3%(9/27)、66.7%(18/27),无残留者bcl2高、低表达分别占72.4%(21/29)、27.6%(8/29),p15分别为27.6%(8/29)、72.4%(21/29);原发灶大小、颈淋巴结有无转移和放疗后有无肿瘤残留其bcl2、p15的表达水平均差异无统计学意义,P>0.05。bcl2或p15高表达组与低表达组的生存率差异无统计学意义,P>0.05。结论鼻咽癌组织中bcl2和p15的表达水平对预测鼻咽癌的病情及预后均无重要的价值。
OBJECTIVE:To evaluate the relation between t he level of expression of bcl-2 and p15 in nasopharyngeal carcinoma(NPC) and th e prognosis. METHODS: The expression of bcl-2 and p15 wer e detected by the S-P immunohistochemical method in 56 NPC patients, and analyz ed the relationship of their expression with extent of primary lesion, lymph nod e metastasis, with or without residual after radiotherapy and survival rate. RESULTS:The high and low level of expresses in bcl-2 were 68.0%(17/25) and 32.0%(8/25), 20.0%(5/25) and 80.0%(20/25) in p15, respectively in T_~1-2 stage; were 77.4%(24/31) and 22.6%(7/31) in bcl-2, 38.7%(12/31) and 61 .3%(19/31) in p15 respectively in T_~3-4 ; were 69.8%(30/43) and 30.2%(13/ 43) in bcl-2, 37.2%(16/43) and 62.8(27/43) in p15 respectively in the patient s with lymph node metastasis; but were 84.6%(11/13) and 15.4%(~2/13 ) , 7.7 %(1/13) and 92.3%(12/13) respectively in patients without lymph node metastasis ; The high and low level of expresses in bcl-2 were 74.1%(20/27) and 25 .9%(7/27), 33.3%(~9/27 ) and 66.7%(18/27) in p15 respectively in the patien ts with residual after radiotherapy; but were 72.4%(21/29) and 27.6%(~8/29 ) , 27.6%(8/29) and 72.4%(21/29) in bcl-2 and p15 respectively in patients with out residual after radiotherapy. There were no correlation to the level of expre ssion in bcl-2 and p15 with extent of primary lesion, lymph node metastasis and residual after radiotherapy,P>0.05.Univariate analysis showed that the exp ression of bcl-2 and p15 were no statistically significant in survival rate,P >0.05. CONCLUSIONS: Immunostaining of bcl-2 and p15 ha s no important value for prognosis in nasopharyngeal carcinoma.[
出处
《肿瘤防治杂志》
2005年第6期421-424,共4页
China Journal of Cancer Prevention and Treatment
基金
广西自然科学基金资助(桂科青0007023)
关键词
鼻咽肿瘤
BCL-2
P15
免疫组化
预后
Nasopharyngeal neoplasms
p15
bcl-2
Immunohistochemical, Prognosis
