摘要
目的研究肝移植术后期的死亡率和主要死亡原因, 探讨肝移植术后期导致死亡的主要并发症的风险因素、预防和治疗.方法回顾性地研究1981年2月至1998年4月进行的生存期大于1年的2940例肝移植长期随访结果, 着重分析其主要死亡原因与相关因素.结果肝移植术后第1～10年死亡率依次为20.4%,6.7%,4.5%,3.8%,3.7%、4.6%,3.5%,3.3%,2.9%,1.9%.后期死亡817例,主要原因依次为恶性肿瘤(复发+新生;20.69%)、心血管并发症(11.38%)、各种感染(11.26%)和呼吸系统并发症(9.42%).结论肝移植术后期主要死亡原因为复发或新生恶性肿瘤、心血管并发症、各种感染和呼吸系统并发症.尽早预防和及时治疗这些并发症,成为进一步提高肝移植长期生存率的关键.
Objective To evaluate the rate and the cause of late mortality in liver transplant recipients and to compare the cause of death in relation to age, gender and diagnosis and year of transplantation. To study the prevention and management of these complications. Methods 2940 patients who underwent liver transplantation and survived more than 1 year between February 1981 and April 1998 were included in this analysis and were followed up to March 2000. Results The rate of death of 1-10 year is 20.4%,6.7%、4.5%、3.8%、3.7%、4.6%、3.5%、3.3%、2.9%、1.9%, respectively. 817 patients who survived more than 1 year have died during the follow-up period. The cause of death are shown that recurrent or de novo cancers has remained the most common cause of late mortality, comprising 20.69% of the deaths. This was follow with cardiovascular 11.38%, infection 11.26%, and respiratory 9.42% cause. Conclusion Recurrent or de novo cancers is the most common cause of late mortality. This was follow with cardiovascular liver transplantation, we are beginning to face these complications as the preeminent factor that will ultimately determine patient survival.
出处
《中华肝胆外科杂志》
CAS
CSCD
2005年第4期244-247,共4页
Chinese Journal of Hepatobiliary Surgery
