摘要
目的:通过回顾药物治疗创伤后应激障碍(PTSD)的研究进展,以评价各类药物治疗PTSD的疗效和安全性。方法:通过查阅近期国内外相关文献进行评价。结果与结论:应激早期应用苯二氮类药(BZ)可预防PTSD的发生,但长期应用易导致依赖,停药出现戒断症状,损害认知功能,三环类抗抑郁药和单胺氧化酶抑制剂疗效肯定,但不良反应较多,逐渐被安全有效的新型抗抑郁药特别是选择性5-羟色胺再摄取抑制剂所取代。近年来抗惊厥药和非典型抗精神病药治疗PTSD取得一定的疗效。
OBJECTIVE: By looking back research progress in drug therapy for posttraumatic s tress disorder (PTSD), to evaluate curative effect and the safety o f each kind of drug used for PTSD. METHODS: By looking up recent literatures a t home and abroad. RESULTS & CONCLUSION: Early use of BZ after trauma will prevent from occurring of PTSD, but long term use of BZ can lead to have depend ence, and there will be some abstinent symptoms, cognition function will be da maged after drug withdrawal. Curative effect of TCA and MAOI is confirmative but with a lot of adverse reactions, so safe and effective new type of antidepress ive drugs, especially selective 5-HT reuptake inhibitor will gradually replace them. Anticonvulsants and atypical antipsychotics have already obtained some go od curative effect on the treatment of PTSD in recent years.
出处
《中国医院用药评价与分析》
2005年第2期85-88,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
