摘要
本文用反相高效液相色谱法测定了氯氮平的血药浓度。其在血浆中的最低检测浓度为２０μｇ／ｌ，日内与日间精密度试验ＣＶ均小于５％。同时测定了３１名住院精神分裂症病人的氯氮平血浆浓度，发现氯氮平的剂量在１００－４００ｍｇ／ｄ时与血药浓度呈显著的正相关。血药浓度与疗效及不良反应之间的关系是不明显的。本文并对氯氮平在试验中的不良反应进行了评价。
Clozapine is an atypical antipsychotic.Its plasma concentrations have been determined by using reversed phase HPLC method.The minimal detectable concentration was 20μg/l plasma. The within-day and day to day precisions(CV)of this method were less than 5% respectively.Clozapine plasma concentrations were determined in 31 inpatients. There was a good correlation between the dose and plasma concentration (P<0. 01), though there were no obvious correlations between the concentrations and the curative effects as well as the adverse reactions. At the same time, the adverse reactions of clozapine were cstimated.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1994年第1期27-31,共5页
The Chinese Journal of Clinical Pharmacology
关键词
氯氮平
高效液相色谱
血药浓度
clozapine
HPLC
plasma concentration
schizophrenia
curative effect
adverse reaction
