摘要
目的检测血清中CA125含量,探讨其在肿瘤疾病诊断中的应用价值。方法应用ELISA方法分别检测150例肿瘤患者(38例卵巢癌,22例其他癌,即肝癌、肺癌和胃癌,50例卵巢囊肿,40例子宫肌瘤)和正常对照组40例血清CA125含量。结果卵巢癌、其他癌(肝癌、肺癌和胃癌)、卵巢囊肿和子宫肌瘤患者CA125阳性率分别为78.9%、45.5%、16.0%和2.5%;CA125含量分别为(217.9±225.2)U/ml、(105.8±55.0)U/ml、(67.3±34.7)U/ml和(17.0±7.1)U/ml,正常对照组为(13.4±7.4)U/ml。结论(1)恶性肿瘤患者比良性肿瘤患者CA125阳性率高,均值比较呈显著性差异(t=2.171,P<0.05);(2)妇科恶性肿瘤患者比其他恶性肿瘤患者(肝癌、肺癌和胃癌)CA125阳性率高,均值比较差异不显著(t=1.570,P>0.05);(3)良性肿瘤患者中卵巢囊肿CA125均值与正常对照组比较,有极显著性差异(t=9.281,P<0.001),而子宫肌瘤患者与正常对照组比较则无显著性差异(t=1.170,P>0.05)。CA125检测对妇科肿瘤疾病的诊断价值最大,对肝癌、肺癌和胃癌的诊断有一定参考价值,对良性肿瘤诊断价值有限。
Objective To study the clinical values of determination of serum CA125 levels for the diagnosis of tumor.Methods The serum CA125 levels of 150 cases of tumor(of 38 cases of ovarian cancer,22 cases of the other cancers including lung cancer,liver cancer and gastric cancer,50 cases of ovarian cyst,40 cases of myometrium tumor)and 40 cases controls were respectively detected by enzyme-linked immunosorbent assay(ELISA).Results The serum CA125 positive rate of ovarian cancer,other cancers including lung cancer,liver cancer and gastric cancer,ovarian cyst and myometrium tumor was 78.9%,45.5%,16.0% and 2.5% respectively;the mean CA125 level of them was (217.9±225.2)U/ml,(105.8±55.0)U/ml,(67.3±34.7)U/ml and (17.0±7.1)U/ml respectively,and controls (13.4±7.4)U/ml.Conclusions (1)The mean CA125 level and positive rate in patients with the cancers were significantly highter than those with the benign tumors(t=2.171,P<0.05);(2)The serum CA125 positive rate in the patients with the gynecologic cancer was high,compared with that of the other cancers including lung cancer,liver cancer and gastric cancer,but differences ih mean CA125 level among them was not significant(t=1.570,P>0.05);(3)The mean CA125 level in the patients with ovarian cyst of the benign tumors was singnificantly much highter than those in controls(t= 9.281,P<0.001),and myometrium tumor not significant(t=1.170,P>0.05).The serum CA125 assay plays an important role in diagnosis of gynecologic tumors;for lung cancer,liver cancer and gastric cancer,it is a useful diagnosis method;and for the diagnosis of benign tumors,it is limited.
出处
《国外医学（临床生物化学与检验学分册）》
2005年第4期204-205,208,共3页
Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
