摘要
目的 探讨一种监测羟基磷灰石(Hydroxyapatite ,HA)义眼台植入术后血管化过程的简单方法。方法 10只新西兰大白兔,右眼实施HA义眼台眼眶植入术。术后第1、2、3、4、6、8周行99Tcm 亚甲基二膦酸盐(MDP)显像。在双侧兔眼眶内取相同大小的感兴趣区,分别计算不同时期每只手术兔HA义眼台植入侧与非植入侧眼眶内平均放射性计数比值(R L)。术后第8周摘取HA义眼台行病理组织学检查。结果 术后第1、2、3、4周的R L平均值依次增大,且各周均数间差异有显著性(F =74 91,P =0 0 0 0 )。术后第6和8周的R L平均值与术后第4周比较,差异均无显著性(F =2 0 5 4、3 12 6 ,P =0 2 4 3、0 5 11)。术后第8周病理检查示全部HA义眼台完全纤维血管化。结论 99Tcm
Objective To find a simple and effective way to investigate the vascularization process in hydroxyapatite (HA) orbital implants. Methods Ten New Zealand white rabbits received HA orbital implants. 99 Tc m methylene diphosphonic acid (MDP) images were evaluated quantitatively and qualitatively weekly. Intraorbital radioactivity was measured by placing a circular region of interest within the normal orbit and the implant, respectively. The ratio of radioactivity between the implanted and the nonimplanted orbit (R/L) was calculated. The orbits were harvested after 8 weeks and examined histopathologically. Results The average R/L ratios of the HA orbital implants added up weekly during the first 4 weeks after implantation( F =74.91, P =0.000), while the average R/L ratios of week 6 and week 8 were not higher than that of week 4 ( F =2.054, 3.126, P =0.243, 0 511). All the HA orbital implants completed the vascularization process at week 8. Conclusion 99 Tc m MDP imaging is a sensitive modality for assessing the process of vascularization in ocular HA implants, and for discerning the complete vascularization process.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2005年第2期111-112,i006,共3页
Chinese Journal of Nuclear Medicine
