10Spiro,R. J, , Faltovich,P. J. ,Jacobson ,M, J.& Coulson,R. L. ( 1992 ). Cognitive Flexibility ,Constructivism and Hipertext:Random Access Instruction for Advanced Knowledge Acquisition in Ⅲ-Structured Domains. In T. M. Duffy & D, H. Jonassen(Eds.), Constructivism and the Technology of Instruction:a Conversation (57-75 ). Hillsdale, NJ:Lawrence Erlbaum Associates.
5Kokubo M, Nishimura Y, Shibamoto Y, et al. Analysis of the clinical benefif of intraopera tive radiotherapy in patients undergoing macroscopically cuiative resection for pancleatic cancer [J]. Int J Radiat Oncol Biol Phys, 2000, 48 (4):1081.
6Watanabe O, Kinoshita J Shimizu T, et al Expression of a CD44 bareant and VEGF-C and the implications for lymphatic metastasis and long-term prognosis of human breast cancer [J]. ExpClinCancerRes, 2005, 24 (1):75.
7Kmeuy N. Chemctherapy and carcinoma one small step forward, one step backward [J]. Jelin Oncol, 1995, 13:1287.
8Manuel G B. Jaime F, Careia G, et al. UFT modulated with leucovorin inodvanced colorectal caucer [ J ]. Oncopazexpe-rieuce Oncology, 1997, 54 : 24.
9Jin Q, Hemminki K, Enquist K, et al. Vascular endothelial growth factor polymorphisms and prgnosis [ J ]. Clin cancer Res, 2005, 11 (10) : 3647.
