摘要
本文观察了二妙散（Ｅｒ－ＭｉａｏＳａｎ，ＥＭＳ）和组成该方的单味药黄柏（ｃｏｒｔｅｘｐｈｅｌｌｏｄｅｎｄｒｉ，ＣＰ）和苍术（ｒｈｉｚｏｍａａｔｒａｃｔｙｌｏｄｉｓ，ＲＡ）对植皮小鼠皮片存活时间和细胞免疫功能的影响，并以抗小鼠胸腺细胞血清（ａｎｔｉｔｈｙｍｏｃｙｔｅｓｅｒｕｍ，ＡＴＳ）作为阳性对照。结果表明：用药各组移植皮片的半数生存期均有明显的延长，与生理盐水组相比Ｐ＜０．０５～０．０１。ＥＭＳ，ＣＰ和ＡＴＳ组的细胞免疫功能明显地受到抑制，其外周血Ｔ细胞值和脾细胞毒指数与生理盐水组比较Ｐ＜０．０１～０．００１，ＲＡ组的抑制作用较弱。上述结果提示，实验用药各组植皮小鼠的细胞免疫功能都有一定抑制作用，其抑制强度的顺序为ＡＴＳ＞ＥＭＳ＞ＣＰ＞ＲＡ。
The effect of Er-Miao-San( EMs),cortex phellodendriCP), rhizomaatractylodis ( RA )and antithymocyte serum(ATS)on median survival time(MST)ofskin allograft and cellular immunity in mice were reported.The results showed thatthese drugs had a significant survival prolongation,effecton skin allograft, and a decrease in peripheral blood T cell,as well as a reduction ofsplenocytotoxic index formice.The ralative order of the suppressive potency was ATS>EMS>CP>RA,but both CP and RA was coordinated in EMS.It was considered that Er-Miao-San,CP and RA possessedthe immunosuppressiveeffect on cellular immunity in skin-allografting mice.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第1期34-36,共3页
Chinese Journal of Pathophysiology
关键词
皮肤移植
免疫功能
二妙散
Medicine, Chinese, Skin,Transplantation, heterogous,Immunity, cellular,Mice
