摘要
目的:探讨TMD患者关节液中NPY的水平与关节源性疼痛的关系。方法:用放射免疫测定法检测TMD患者的 126侧关节和健康志愿者的 32侧关节的关节液标本中NPY的含量。患者的关节液标本分为疼痛组(n=90)和无痛组(n=36); 32名正常志愿者的 32侧关节液设为对照组 (n=32)。结果:关节液中NPY含量:疼痛组 133. 5±46. 7pg/ml,无痛组 99. 7±25. 9pg/ml,对照组83. 3±28. 4pg/ml。统计学检验各组间比较均有显著性差异 (P<0. 05 )。结论:患者关节液中NPY水平,疼痛组显著高于无痛组,表明患者关节内存在炎症反应,关节疼痛与关节液中NPY的水平增高密切相关。
Objective: To investigate the relationship between the concentration of neuropeptide Y (NPY) in synovial fluid and temporomandibular joint (TMJ) pain. Methods: According to whether patients had pain, the samples from 126 TMJs in temporomandibular disorder (TMD) patients were divided into two groups: ①painful group(n=90) ; ②painless group(n=36). Samples from healthy volunteers served as control group(n=32). Radioimmunoassay was used to examine the concentration of NPY. Results: The concentration of NPY of painful group (133.5±46.7 pg/ml) was significantly higher than that of painless group (99.7±25.9 pg/ml) and control group (83.3±28.4 pg/ml). Conclusion: The level of NPY in synovial fluid of patients was significantly higher than that of healthy individuals. Among the patients, there was a significant difference between painful group and painless group. This indicates that there is inflammation in TMJ, and that the NPY level is closely correlated with TMJ pain.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2005年第2期74-76,共3页
Chinese Journal of Pain Medicine
基金
北京军区"十五"医学科学技术研究资助项目(02B011)
