摘要
在继续从云南红豆杉（ＴａｓｕｓｙｕｎｎａｎｅｎｓｉｓＣｈｅｎｇｅｔＬ．Ｋ．Ｆｕ）树皮中寻找抗肿瘤活性成分的研究中，又分离出７个紫杉烷类二萜化合物，经光谱解析（ＭＳ，１ＨＮＭＲ，１Ｈ－１ＨＣＯＳＹ，１３ＣＮＭＲ，１３Ｃ－１ＨＣＯＳＹａｎｄ１３Ｃ－１ＨＣＯＬＯＣ），鉴定其中５个为已知化合物：７－ｅｐｉ－１０－ｄｅａｃｅｔｙｌｔａｘｏｌ（Ｉ），７－ｅｐｉ－１０－ｄｅａｃｅｔｙｌｃｅｐｈａｌｏｍａｎｎｉｎｅ（ＩＩ），１０－ｄｅａｃｅｔｙｌｔａｘｏｌ（ＩＩＩ），１０－ｄｅａｃｅｔｙｌｃｅｐｈａｌｏｍａｎｎｉｎｅ（ＩＶ）和１０－ｄｅａｃｅｔｙｌｂａｃｃａｔｉｎＩＩＩ（ＶＩＩ）；２个新化合物是１３（２′，３′－ｄｉｈｙｄｒｏｘｙ－３′－ｐｈｅｎｙｌ）－ｐｒｏｐｉｏｎｙｌｂａｃｃａｔｉｎ，ＩＩＩ（Ｖ）和９－ｄｅｏｘｏ－９α－ｈｙｄｒｏｘｙｔａｘｏｌ（ＶＩ），分别命名为云南红豆杉醇（ｙｕｎｎａｎｘｏｌ）和云南红豆杉胺（ｙｕｎｎａｎｘａｍｉｎｅ）。
On the continuing study for discovering antitumor agents from the stem bark of Taxus Yunnanensis,seven taxane diterpenoids were isolated. Five of them are known compounds ,their structures were elucidated,on the basis of MS,1HNMR,1H-lH COSY,13CNMR,13C-1H COSY and 13C-H COLOC analyses,as 7-epi-10-deacetyl taxol(Ⅰ),7-epi-10-deacetyl cephalomannine(Ⅱ),10- deacetvl taxol(Ⅲ),10-deacetyl cephalomannine(Ⅳ),10-deacetyl baccatin Ⅲ(Ⅶ).The structures of two the unknown compounds , named as yunnanxol(Ⅴ)and yannanxamine(Ⅵ),were elucidated as 13(2′,3′- dihydroxy-3′-phenyl)-propionyl baccatin Ⅲ and 9-deoxo-9α-hydroxy taxol respec- tively.
出处
《药学学报》
CSCD
北大核心
1994年第10期751-757,共7页
Acta Pharmaceutica Sinica
关键词
云南红豆杉
紫杉烷类
二萜
Taxus Yunnanensis
Taxane diterpenoids
Yunnanxol
Yunnanxamine
