摘要
目的分析慢性疲劳综合征(chronicfatiguesyndrome,CFS)患者的临床表现及相关检查结果,为探索病因及治疗方案提供依据。方法对82例CFS患者建立表格病历,总结临床表现;SCL90等量表进行心理学测试;蛋白质印迹法检测血浆中抗博尔纳病病毒(Bornadiseasevirus,BDV)p24抗体;高压气相色谱分析检测红细胞膜上n6脂肪酸水平;酶学方法检测血浆左旋肉碱水平。结果CFS患者年龄主要分布在21～50岁之间,无性别差异,疲劳的伴随症状中,记忆力和/或注意力下降最为突出;大部分患者(57/82)存在SCL90结果异常;与健康对照组相比,CFS患者抗BDV p24抗体阳性检出率高[11%vs0%,χ2=6.673,P=0.010],n6脂肪酸中花生四烯酸(ARA)水平明显低(P<0.05),左旋肉碱水平低[(6±3)vs(8±4),t=2.025,P=0.045]。结论CFS患者以中青年多见,70%合并心理学异常,11%存在BDV感染,部分合并营养及能量代谢障碍。
Objective To analyze the clinical characteristics of Chinese patients suffering from chronic fatigue syndrome (CFS) and provide clinical and laboratory evidence for the study of its etiology and treatment.Methods 82 patients with CFS diagnosed based on the CDC criteria 1994 were recruited. History was collected, and physical examination was made. SCL-90 and memory test were used, and Hamilton Anxiety Rating Scale was used to those showing depression and/or anxiety. Laboratory examination, including examination of electrolytes, blood sugar, creatinine, bilirubin, alkaline phosphatase, alanine trasaminase, etc, was conducted. Western blotting was used to detect the protein-24 of Borna disease virus (BDV) in the plasma of 61 patients and 73 healthy controls. High-pressure chromatography was conducted to detect n-6 fatty acids on the membrane of erythrocytes of 42 patients and 37 healthy controls. Plasma L-carnitine in 61 patients and 73 healthy controls was detected by zymological analysis. In different examinations sex and age-matched controls were used.Results Most of the patients were 21~50 years old (74/82, 90.24%). No gender difference was found. The patients usually had 4~6 symptoms besides distinctive fatigue. Descent of remembrance and/or attention was the most conspicuous accompanying symptoms (69/82, 84.15%). Abnormalities in SCL-90 scores were present in 57 patients (69.51%), ~e.g , somatization existed most commonly (32/82, 39.02%), and anxiety and depression were 20.73% (17/82) and 18.29% (15/82) respectively. The prevalence of anti-BDV-p24 antibody was 20.73% (17/82), significantly higher than that of the controls (0%, χ2=6.673,P=0.010). The arachidonic acid level was significantly lower in the CFS group than in the controls (P>0.05) and there were no differences in linoleic acid and ETA (both P>0.05). The level of L-carnitine was 6.4336±3.4225, significantly lower than that of the control group (7.6666±3.5819, t=2.025,P=0.045) and the L-carnitine level was increased 2 weeks after supplementary treatment, together with improvement of symptoms.Conclusion Most of the CFS patients are young and middle-aged. Descent of reorganization is common in these patients. Psychological abnormalities exist in most patients. Some patients are infected with BDV, some with deficiency of nutrition and/or abnormality of energy metabolism.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2005年第10期701-704,共4页
National Medical Journal of China
