摘要
目的:探讨S100β与血管性认知损害(VCI)的关系。方法:①认知功能评价:运用简易智能状态量表(MMSE)及临床记忆量表(CMS)评估认知功能;②分组:轻度VCI组25例,中、重度VCI组33例;无认知损害脑梗死组30例及正常对照组30例;③用酶联免疫吸附法(ELISA)测定患者及对照组血清S100β含量。结果:中、重度VCI组的血清S100β浓度[(0.64±0.06)μg·L-1]显著性高于轻度VCI组[(0.42±0.08)μg·L-1]、无认知损害脑梗死组[(0.41±0.12)μg·L-1]及正常对照组[(0.39±0.11)μg·L-1],均具有显著性差异(P<0.05);轻度VCI组的血清S100β浓度稍高于无认知损害脑梗死组及正常对照组,但无显著性差异(P>0.05);相关性分析示中、重度VCI组MMSE总分及记忆商(MQ)值皆与血清S100β含量呈显著性负相关(P<0.05),而轻度VCI组MMSE及MQ值均与血清S100β含量无显著性相关(P>0.05)。结论:血清S100β有可能作为观察中、重度血管性认知(包括记忆)损害的生化指标。
Aim: To explore the relationship between S100β and vascular cognitive impairment (VCI). Methods: 1111111 Cognitive evaluation: mini-mental state examination ( MMSE) and clinical memory scale ( CMS) were used to evaluate the patients' cognitive function;·Grouping:the mild VCI group with 25 cases,the moderate and severe group with 33 cases,the cerebral infarction group of 30 cases without cognitive impairment and the controlled group with 30 cases; 3333333The S100β concentration in serum was determined by ELISA. Results: The serum S100β concentration of the moderate and severe VCI group [(0.64±0.06) μg·L-1] was markedly higher than that of the mild VCI group [(0.42±0.08) μg·L-1],of the cerebral infarction group without cognitive impairment [(0.41 ±0.12)μg·L-1 ] and of the controls [(0.39 ±0.11) μg·L-1 ]with significant difference (P< 0.05); the serum S100β concentration of the mild VCI group was slightly higher than that of the cerebral infarction group without cognitive impairment and of the controls without remarkable difference ( P > 0.05); MMSE score and Memory Quotient in the moderate and severe VCI group were negatively related to the serum S100β concentration significantly ( P < 0.05); while the MMSE score and the Memory Quotient had not remarkable relationship with the serum S100β concentration in the mild VCI group ( P > 0.05) . Conclusion: S100β might act as the observational marker of moderate and severe vascular cognitive (including memory)impairment in biochemistry.
出处
《中国临床神经科学》
2005年第1期9-11,共3页
Chinese Journal of Clinical Neurosciences
基金
国家自然科学基金资助项目(No.30270483)
