摘要
本文通过预先将醛和四氯化锡进行配位形成高活性的醛中间体 ,同时采用滴加高烯丙醇的方法高收率和高选择性地合成了 2 ,4,6-三取代四氢吡喃 .
Recently, Prins-cyclization has been widely used to synthesize tetrahydropyrane derivatives, but allyl transferring and side chain exchange will take place during the process, and the yields of the expected tetrahydropyrans were poor. In this paper, we report a new route to prepare 2,4,6-trisubstituted tetrahydropyranes with a high selectivity and excellent yields by previously coordinating aldehyde with tin(Ⅳ) chloride, then adding homo-allyl alcohol drop by drop.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2005年第3期452-455,共4页
Chemical Journal of Chinese Universities
基金
国家教育部重点科研基金 (批准号 :0 0 0 2 5 )
国家自然科学基金 (批准号 2 0 3 72 0 3 3 )
南开大学科技创新基金资助 .
