摘要
目的:分析慢性心力衰竭的治疗药物应用情况。方法:将1973年7月—2002年7月收治的慢性心衰住院病例按每10年分成3个亚组,对药物治疗变迁及其与病因、年龄、性别和心功能的关系进行分析。结果:共3060例次。平均年龄(61.15±14.73)岁。利尿剂、洋地黄制剂和硝酸酯为主要用药,血管紧张素转换酶抑制剂(ACEI)、β-阻滞剂和血管紧张素受体拮抗剂(ARB)的应用逐渐增加。而且以冠心病应用居多。利尿剂、硝酸酯类、ACEI、ARB、长效二氢吡啶钙拮抗剂及α、β-阻滞剂以60岁以上年龄组居多,应用ACEI者男性多于女性,β-阻滞剂应用无性别和年龄差异。ACEI和β-阻滞剂的使用率分别为59.7%和20.8%,停用率分别为5.2%和29.1%。结论:慢性心力衰竭住院病例的治疗药物以利尿剂、硝酸酯和洋地黄制剂为主;ACEI、β-阻滞剂的应用尚未达到ACC/AHA慢性心力衰竭诊治指南所推荐的要求。
Objective To investigate medication of hospitalized patients with chronic heart failure CHF during past 30 years in our hospital and provide more information on the treatment strategy of CHF. Methods All data was taken from the hospitalized cases with CHF from July 1973 to July 2002. Database was established every 10 years. Results The counts were altogether 3 060. The diuretics digitalis and nitride dominated the drug therapy in hospitalized patients with heart failure. The users of diuretics nitride angiotensin conversion enzyme ACE inhibitors β-blockers and angiotensin receptor blockers(ARB) increased year after year. The drugs were mostly used in coronary heart disease and rheumatic heart disease. The users of ACE inhibitors diuretics nitride ARB in the group over 60 years old were more than in the group under 60 years old. ACE inhibitors were used more in men than in women. The users of β-blockers had no diversities between men and women. ACE inhibitors were given in 59.7% of the patients and β-blockers in 20.8% at the interview.The ceasing users of the two drugs were 5.25% and 29.27%. Conclusion The conventional drugs still dominate the majority therapy for the CHF. There is a great gap between optimal medical strategy and clinical practice in the management of CHF but the users of ACEI and β-blocker increase significantly.
出处
《天津医药》
CAS
北大核心
2005年第3期135-138,共4页
Tianjin Medical Journal
基金
天津市科委重点资助项目(项目编号:033111311)
