摘要
目的 了解病毒性心肌炎 (VM)患儿血浆血管紧张素Ⅱ (AngⅡ )水平和心功能的变化及卡托普利 (CAP)治疗VM的效果。方法 采用放射免疫法测定血浆AngⅡ浓度和多普勒超声心动图检测心功能 ;检测VM组 (n =60 )治疗前、后 (CAP组、常规组及对照组各 30例 )血浆AngⅡ浓度和心功能。结果 1 .VM患儿血浆AngⅡ水平较对照组明显升高 ,心肌收缩舒张功能明显减退 ,有显著性差异 ,AngⅡ水平与心收缩舒张功能显著相关 ;2 .与治疗前比较两组VM患儿治疗后AngⅡ水平下降 ,心肌收缩功能好转 ,有显著性差异 ,CAP组舒张功能明显好转 ,常规组无明显好转 ;治疗后两组比较 ,CAP组AngⅡ水平和心收缩舒张功能明显好转 ,与常规组比较有显著差异。结论 VM患儿血浆AngⅡ水平明显增高是导致心肌收缩舒张功能减退的重要因素 ;应用CAP治疗VM ,能降低血浆AngⅡ浓度 ,改善心功能。
Objective To explore the changes of plasma angiotensinⅡ (AngⅡ) and cardiac function,and the curative effect of children with acute viral myocarditis (VMC) treated with captopril(CAP).Methods Concentrations of plasma AngⅡ were measured with radio-immunity and cardiac function was detected by Doppler echocardiography for the VMC group (n=60) before and after treatment [the CAP group (n=30), the routine group (n=30) and the control group (n=30)].Results 1. The level of plasma AngⅡ significantly increased and the contractive and diastolic function obviously declined in children with acute VMC. There was a significant difference between VMC group and control group, with a significant correlation between the level of AngⅡand the contractive diastolic function.2. Compared with the level before treatment, the level of AngⅡ decreased and the contractive function obviously ameliorated in two groups; the diastolic function obviously ameliorated in the CAP group and did not ameliorate in the routine group after treatment. In CAP group the level of AngⅡ and the cardiac function significantly improved; there were statistical differences between the two groups after treatment.Conclusions 1.The increase of the plasma AngⅡ was an important factor for decrements of the contractive and diastolic function in acute viral myocarditis.2.It could decrease the concentration of plasma AngⅡ and ameliorate cardiac function in children with acute VMC treated with captopril,which was an effective therapy for acute VMC.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第3期262-263,共2页
Journal of Applied Clinical Pediatrics
