摘要
目的 探讨葛根素治疗妊娠期高血压疾病患者的母婴结局和血浆中一氧化氮 (NO)、血栓素B2(TXB2)、内皮素(ET)、6 酮 前列腺素F1α(6-Keto-PGF1α)的变化。方法 2001年 1月至 2004年 6月广东省妇幼保健院用葛根素(A组)和硫酸镁(B组)分别治疗 50例重度子疒间前期的患者,观察两组平均动脉压、尿蛋白、胎心率异常、新生儿窒息和产后出血、羊水混浊、新生儿出生体重等情况以及治疗前后血浆NO、TXB2、ET、6 Keto PGF1α的变化情况。结果 A组治疗前后平均动脉压分别为 ( 125.5±13.3 )mmHg( 1mmHg=0 133kPa)和(103.0±15.4)mmHg,血压有显著性下降 (P<0.05 ),B组治疗前后平均动脉压为 ( 123.0±12.3 )mmHg和(119.0±13 7)mmHg,差异无显著性(P>0.05),两组治疗前后 24h尿蛋白分别为A组 (3 91±0.46)g和 (1.53±0 61)g;B组(3.89±0.39)g和(1.50±0.35)g,两组治疗前后均有显著差异性 (P<0.05)。两组血浆细胞因子治疗前后均有显著差异性(P<0.05)。B组胎心异常率为 22%,明显高于A组(P<0.05)。结论 葛根素治疗妊娠期高血压疾病时能有效降低平均动脉压,改善母血中NO、TXB2、ET、6-Keto-PGF1α的水平,对治疗有积极的作用。
Objective To discuss the effect of puerarin on outcomes and the plasma concentrations of ET,NO,TXB_(2) and 6-Keto-PGF1α_( )of women with hypertensive disorder complicating pregnancy.Methods 100 women with pre-eclampsia were studied while treated with puerarin and magnesium sulfate in group A and B.Blood pressure,urine protein,postpartum hemorrhage,neonatal asphyxia and concentrations of NO,ET,TXB_(2) and 6-Keto-PGF1α in blood were monitored.Results There was significant difference in mean arterial blood pressure between before and after treatment in group A(P<0.05).No difference was found in group B(P>0.05).In maternal plasma the concentrations of ET,NO,TXB_(2) and 6-Keto-PGF1α were significantly different between before and after treatment in group A and B(P<0.05)._( ) Group B had higher incidence of abnormal fetal heart rate than group A (P<0.05).Conclusion It is showed that puerarin can effectively control blood pressure and well banlance circulating levels of NO,ET,TXB_(2) and 6-Keto-PGF1α in women with hypertensive disorder complicating pregnancy.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2005年第3期158-160,共3页
Chinese Journal of Practical Gynecology and Obstetrics
基金
广东省医学科学技术研究基金资助项目(项目号:A2002940)
关键词
妊娠期高血压疾病
葛根素
硫酸镁
治疗
Hypertensive disorder complicating pregnancy Puerarin Magnesium sulfate
