摘要
不饱和脂肪酸（ＬＡ）浓度为２５μｈ／ｍｌ，对人肺腺癌细胞系（ＳＰＣ－Ａ１）细胞和二倍体人胚肺细胞系（ＨＬＦ）细胞抑制率分别为：９８．４±２．２％，１８．０±２．１％（Ｐ＜０．００１）。表现为对恶性细胞的选择性抑制作用。ＳＰＣ－Ａ１对５μｇ／ｍｌＬＡ无反应，１μＭ丝裂霉素Ｃ（ＭＭＣ）对ＳＰＣ－Ａ１细胞抑制率为４３．４±２．９％而当用１μＭＭＭＣ处理这种对５μｇ／ｍｌＬＡ无反应的ＳＰＣ－Ａ１时，抑制率提高到６５．２±５．６％（Ｐ＜０．００１）表明低浓度ＬＡ能提高ＳＰＣ－Ａｌ细胞对ＭＭＣ的敏感性。
The fact that long-term cultured human lung adnocarcinoma cell line(SPC-A1)and normal diploid human fetal lung cells(HLF)in culture were suppressed for98.4 ± 2.2% and 18.0 ± 2.1% respectively by 25 μg/ml of polyunsaturated fatty acid,linoleic acid(LA)in medium(P<0.001)indicated that LA might specially suppressthe growth of malignent cells other than normal cells. SPC-Al cells treated with 5μg/ml of LA but no response could be seen had been suppressed for 65.2±5.6%whenadding mitomycin C(MMC) into culture system at a final concentration of 1 μM.Whereas at such a concentration MMC only suppressed SPC-A1 cells for 43.4±2.9%(P<0.001).This result suggested that a lower concentration of LA could enhance thesensitivity of malignant cells to MMC.
出处
《上海医学》
CAS
CSCD
北大核心
1994年第11期635-637,共3页
Shanghai Medical Journal
