摘要
以回避反应为指标，检测了１９只２４月龄老年Ｗｉｓｔａｒ大鼠的学习记忆能力。于老年大鼠双侧海马或第三脑室移植新生大鼠颈上神经节后２周，观察到学习记忆能力显著改善，海马内移植后以避暗反应检查，进洞潜伏期自１７．５±１５．５ｓ延至３７６．７±２７０．８ｓ（ｐ＜０．０１）。同期非移植或假移植术大鼠的学习记忆能力仍处于较低水平。第三脑室内移植后以跳台法检测，大鼠为回避电击在平台停留５ｍｉｎ所需电击时间为１１．７±６．３ｓ，与移植前对照值６４．７±３２．３ｓ比较ｐ＜０．０１。行为实验后对移植区进行了荧光组织化学及电镜检查，结果表明，应用脑内移植技术改善老年大鼠的记忆损害可能与补充单胺类递质有关。
erformances of learning and memory tasks were elamined with methods ofavoidance response in 24 months Wistar rats(n=19),It was observed that theimprovement of learning and memory ability at the second weeks after transplan-tation of superior cervical ganglion into the bilateral dorsal hippocampi or thethird cerebral ventricle of aged rats. Mean latency to re-enter the dark chamberwas prolonged from 17.5± 15.5s to 376.7±270.8s(p<0.01). The ability of lear-ning and memory of aged rats was still kept a lower level in the same period innormal control or pseudotransplantation rats,After transplantation of Superiorcervical ganglion cells into the third cerebral ventricle the learning and memoryability of aged rats was improved also,In the end of the bihaveoral experiments,the histofluorescence and electron microscopic examinations of the grafts wareperfomed.The above results suggested that improvement of memory function of agedrats may be due to supplement of monoamine transmitter by the transplanted sup-erior cervical ganglion tissue in the brain.
出处
《基础医学与临床》
CSCD
1994年第6期35-38,共4页
Basic and Clinical Medicine
基金
国家自然科学基金
关键词
移植颈上神经节
海马
记忆
老年
transplantation superior cervical ganglion hippocanpus memory aged rats
