摘要
实验用Ｗｉｓｔａｒ大鼠５６只，随机分为四组，即对照组，１５０ｍｇ／ＬＮａＦ组，７５ｍｇ／ＬＡｓ２Ｏ３组和１５０ｍｇ／ＬＮａＦ＋７５ｍｇ／ＬＡｓ２Ｏ３联合组。各组动物于染毒６个月时收集２４小时尿液，进行尿氟、尿砷和尿羟脯氨酸含量分析。结果表明：氟砷联合作用于机体时，砷对氟的排泄具有某种抑制作用，而氟对砷的排泄无明显影响。各实验组尿羟脯氨酸含量均明显高于对照组，砷组高于氟组和氟砷联合组。表明氟和砷均对胶原代谢有明显影响。其联合作用显示出氟具有拮抗砷对胶原代谢的影响。胶原代谢的紊乱在氟中毒骨骼异常改变中起着重要作用。同时这种紊乱可能是砷中毒皮肤异常改变的一个重要中间环节。
56 Wistar rats were fed on wtiter containing 150 mg/L NaF,75mg/LAs2O3 and the mixture of 150mg/L NaF plus 75 mg/L As2O3 for six months.Urine was collected for 24 hours.The contents of urinary Hyp,F and As were analysed in rats. Results showed that arsenic could inhibit the excretion of fltiorine.Contents of urinury Hyp in three test groups were more than those in control group.But the conmtents in arsenic group were more than in the other groups. The results suggested that the metabolism of collagen could be affected by both arsenic and fluorine. In the condition of arsenic─fluorine combined action. fluorine could reJduce the action of arsenic. Abnormal metabolism of collagen has important action on the harm of bones in fluorsis and may be an important mediating factor on the harm of skin in arsenism.
出处
《地方病通报》
1994年第4期50-51,共2页
Endemic Diseases Bulletin
基金
国家自然科学基金
关键词
地方病学
氟
羟脯氨酸
动物实验
大鼠
砷
Fluorine
Arsenic
Hydroxyproline
Combination action
Animal experiment
Wistar rat
