摘要
作者由人参根中分离出一种葡聚糖（ＧＲ－５Ｎ）和两种酸性杂多糖（ＧＲ－５Ａ－ＵＬ和ＧＲ－５ＡＵＨ）。ＧＲ－５Ｎ是由葡萄糖（ＧＬＣ）组成，而ＧＲ－５ＡＵＬ和ＧＲ－５ＡＵＨ是由半乳糖醛酸（ＧａｌＡ）、半乳糖（Ｇａｌ）、鼠李糖（Ｒｈａ）和阿拉伯糖（Ａｒａ）组成。ＧＲ－５Ｎ、ＧＲ－５ＡＵＨ、ＧＲ－５ＡＵＬ的分子量分别为２５０００、７２０００和５５００。糖甙键分析表明，ＧＲ—５Ｎ具有１→４连接的ＧＬＣ为主链，但在其中的６位上有分枝。ＧＲ—５ＡＵＬ和ＧＲ—５ＡＵＨ是果胶类多糖。ＧＲ－５Ｎ具有一定的抗肿瘤作用，它的ＩＬＳ（Ｉｎｃｒｅａｓｅｉｎｌｉｆｅｓｐａｎ）为４６．８％。
One
gluca(GR-5N)and two acidic polysaccharides(GR-5AUL and GR- 5AUH)were isolated from the
roots of Panax ginseng C,A. Meyer, GR-5N was composde of Glc onlvbut GR- 5AUL and
GR-5AUH were composed of GalA, Gal,Rha,Ara ,mainly. The molecu- Iar weight of GR-5N ,
GR5AUL and GR-5AUH were 25 000 ,72 000 and 5 500 , respectively,dctected by HPLC with 0.2
mol /L NaCL as eluant. The molecul ar weight of GR- 5AUL andGR- 5AUH were increased to 760
000 and 42 000 if eluated with water in the HPLC condition,indlcating that the two acidic
polysaccharides were from larger in(molecules) in water。 Glycro-syl linkage anal ysis showed
GR- 5N has a l→4 linkage main cbainand was branched in the 6position of the l→4 GLC in the
main chain; Its structure was similar to amylopeetis but GR-5AUL and GR- 5AUH were pectic
polysaccharidcs. GR-5N has anti-tumor activity. The ILS(increase in life span)of GR- 5N was 46.
8%when the dosage was l00 mg/(kg·day).
出处
《白求恩医科大学学报》
CSCD
1994年第5期439-441,共3页
Journal of Norman Bethune University of Medical Science
关键词
人参
化学性质
抗肿瘤作用
多糖
polysaccharides/chem anti- tumor
activity
glucan
pectine
