摘要
目的 了解我院耐甲氧西林金黄色葡萄球菌 (MRSA)的医院感染 ,防止医院 MRSA发生和暴发流行。方法 对我院 2 0 0 2年 1～ 12月发生的 14例 MRSA医院感染病例进行回顾性分析。结果 2 0 0 2年共分离出MRSA2 6株 ,占金黄色葡萄球菌的 2 7.37% ,其中 14株为医院感染株 ;MRSA医院感染者主要来自外伤 (7例 )、重度烧伤 (4例 )患者 ,其次是恶性肿瘤 (2例 )和脑出血患者 (1例 ) ;其中大多数病例接受了气管插管、使用呼吸机等侵入性操作 ;感染部位多分布在皮肤和软组织、手术切口和下呼吸道 ;MRSA感染前均使用≥两种抗菌药物 ,其中三代头孢菌素的应用频率最高。结论 严重的基础疾病、接受侵入性操作、长期应用广谱抗菌药物可能是MRSA感染的危险因素 ,必须加强抗菌药物合理应用的管理和严格的消毒隔离措施。
OBJECTIVE To investigate the features of MRSA nosocomial infection and prevent the MRSA nosocomial infection and outbreak. METHODS The retrospective analysis on 14 inpatients from Jan 2002 to Dec 2002 was carried out. RESULTS A total of 95 Staphylococus aureus strains were detected, including 26 (27.30%) MRSA. Fourteen MRSAs were isolated from nosocomial infection inpatients. Fourteen MRSA patients consisted of 7 cases of injury, 4 cases of severe burn, 2 with malignant tumor and 1 with brain bleeding. Most of the cases had received invasive operation, such as mechanical ventilation and tract insertion. The common infected sites were skin, soft tissue, surgical incision and lower respiratory tract. Two or more kinds of antibiotics were used for each patient before suffering MRSA nosocomial infection. The most frequency used antibiotics was the 3rd generation cephalosporins. CONCLUSIONS Severe diseases, invasive operation, long duration of the treatment with broad spectrum antimicrobials may be the risk factors. Rational utilization of antibiotics and strict disinfection are necessary for prevention of MRSA nosocomial infection.
出处
《中华医院感染学杂志》
CAS
CSCD
2004年第9期1055-1057,共3页
Chinese Journal of Nosocomiology
