摘要
目的 探讨短期应用地塞米松促胎肺成熟对妊娠期糖尿病 (GDM )孕妇及其围产儿预后的影响。方法 将 70例妊娠期糖尿病患者根据产前有无使用地塞米松促胎肺成熟分为使用组与未用组。使用组根据产前使用地塞米松促胎肺成熟的总剂量又分为≤ 10mg和≥ 2 0mg剂量组。使用组根据从产前使用地塞米松至分娩的时间又分为≥ 2 4h组和 <2 4h组。收集临床资料对比各组母体及围产儿并发症的发生率。结果 产前用地塞米松的GDM患者 ,产后血糖控制不满意比例低于未用药组 ;用药组胎儿窘迫、感染和低血糖的发生率低于未用药组 ;≥ 2 0mg组胎儿窘迫、新生儿低血糖发生率低于未用药组。≤ 10mg剂量组Apgar评分明显高于≥ 2 0mg剂量组 ,有显著性差异 (P <0 0 5 ) ;<2 4h组胎儿窘迫、新生儿低血糖发生率高于≥ 2 4h组 ,无显著性差异。结论 短期小剂量应用地塞米松促胎肺成熟对妊娠期糖尿病孕母及其围产儿无近期的不良影响 。
Objective To investigate the effect of dexamethasone on maternal complications and perinatal prognosis in gestational diabetes mellitus (GDM). Methods Seventy cases of GDM from 1996 to 2002 were divided into dexamethasone treated group and control group. The dexamethasone treated group was divided into two subgroups: ≤10 mg group and ≥20 mg group according to the dosage of dexamethasone. The treated group were divided into two subgroups: ≥24 h group and <24 h group according to the time from administration to labor. The clinical data were collected and the incidence of maternal and perinatal complications was compared among the groups. Results The incidence of maternal complications and the ratio of unsatisfactory control of blood glucose were lower in dexamethasone treated group, but without significant difference. The incidence of fetal distress and infection and hypoglycemia was lower in dexamethasone treated group, but without significant difference. The incidence of hyperbilirubinemia and infection was lower in the ≤10 mg group, while the incidence of fetal distress and hypoglycemia was higher, but without significant difference ( P >0 05). The 5 min Apgar scores in the ≤10 mg group was significantly higher than those in the ≥20 mg group ( P <0 05). The incidence of fetal distress and hypoglycemia was higher in the <24 h group, while the incidence of hyperbilirubinemia and infection was higher in the ≥24 h group, but without significant difference. Conclusion There is no near future harmful effect of dexamethasone on maternal complications and perinatal prognosis.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2003年第4期428-430,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
