摘要
４９例梗阻性黄疸患者（实验组）和８１例无黄疸的胆系疾病患者（对照组）围手术期外周血的内毒素（ＥＴ）检测结果表明，实验组：①术前ＥＴ阳性率明显高于对照组（Ｐ＜０．００１）；②术后１０～１２ｄ夹闭Ｔ／Ｙ管后ＥＴ阳性率明显低于术前和夹管前（Ｐ＜０．００１）；③伴急性化脓性胆管炎（ＡＣＳＴ）的患者ＥＴ阳性率明显高于无ＡＣＳＴ的患者（Ｐ＜０．００１）；术前口服胆盐的患者ＥＴ阳性率则显著低于未口服胆盐者（Ｐ＜０．００１）．作者认为，本组梗阻性黄疸患者中出现的肾功能障碍、胃肠道出血以及２例患者的死亡，至少部分地与内毒素血症有关。
Endoxin (ET) in the peripheral blood from 49 patients with obstructive jaundice (OJ) and 81 patients with nonicteric biliary tract diseases (NIBD) in the perioperative period was assayed.The results showed that in patients with KJ(1) the preoperative blood ET positive rate was significantly higher than that in patients with NIBD (P<0. 001); (2) clamping of the T/Y tubes 10～12 days postoperatively resulted in a much lower blood ET positive rate as compared with that before operation as well as before clamping (P<0.001); (3) blood ET positive rate in patients with acute suppurative cholangitis was much higher than in patients without this complication (P<0. 001); (4) preoperative oral administration of blie salts causel a significantly lower blood ET positive rate (P<0. 001).1t is considered by the authors that in the present study, endotoxemia is at least partly responsible for renal function disturbance, gastrointestial bemorrhage and 2 cases of death in patiens with OJ.
