摘要
目的:探讨肝豆状核变性(HLD)患者Ⅲ型前胶原(PCⅢ)和转化生长因子-β1(TGF-β1)的变化及 临床意义。方法:对112例HLD患者和30例正常对照组用放射免疫分析检测PCⅢ和用酶免法检测TGF-β1 的水平。结果:HLD组PCⅢ和TGF-β1的水平显著高于正常对照组(P<0.01)。结论:血清PCⅢ和TGF-β1 的测定可较好地反映肝纤维化的程度。
Objective To investigate the clinical significance of the changes of serun procollagen typeⅢ (PCⅢ) and transforming growth factor betal (TGF-β 1) levels in patients with hepatolenticular degeneration (HLD). Methods Serum PCⅢ levels (with RIA) and TGF-β 1 levels (with ELISA) were determined in 112 patients with HLD and 30 controls. Results The levels of serum PCⅢ and TGF-β 1 in HLD patients were significantly higher than those in the controls (P<0.01). Conclusion Determination of serum PCⅢ and TGF-β 1 levels might be able to reflect the degree of hepatic fibrosis.
出处
《放射免疫学杂志》
CAS
2005年第1期16-17,共2页
Journal of Radioimmanology
