摘要
目的 :观察夏枯草醇提物对实验性糖尿病大鼠肾脏病变的防治作用。方法 :夏枯草经乙醇、氯仿提取得醇提物 (AEP)。腹腔注射链脲佐菌素后 4周 ,造成大鼠糖尿病模型 (DM ) ,灌胃AEP 10 0mg/kg、2 0 0mg/kg 4周 ,测定血糖、肾功能和肾组织醛糖还原酶活性。结果 :AEP能显著降低糖尿病大鼠尿蛋白 ,AEP 10 0mg/kg能降低血清尿素氮、肌酐含量 ;能显著降低DM大鼠肾组织醛糖还原酶 (AR)活性。结论 :AEP对糖尿病大鼠并发肾脏病变有一定的防治作用 ,其作用机制可能通过抑制醛糖还原酶活性以减轻山梨醇蓄积造成相关组织器官的损害。
Objective: We examined the prevention and cure effect of the Alcohol extract of spica prunellae (AEP) on experimental diabetic nephropathy in rat. Methods: The AEP was obtained by extracting spica prunellae with ethanol and chloroform. After 4 weeks experimental diabetic model was induced by i.p. rats streptozotocin(STZ), DM rats were administratred the AEP 100mg·kg -1 ,200mg·kg -1 for 4 weeks, blood glucose, kidney function and activity of kidney aldose reductase were determined. Results: The AEP decreased significantly urinary protien in diabetic rats. The AEP 100mg·kg -1 decreased blood urea nitrogen(BUN) and creatinine(Cr) in diabetic rats. The AEP deceased significantly activity of kidney aldose reductase in diabetic rats. Conclusions: The AEP had certain degree of preventing diabetic nephropathy. The results suggested that the AEP defect diabetic nephropathy by inhibiting activity of aldose reductase to decrease associated tissue or organ injuries caused by accumulation of sorbitol.
出处
《山西中医学院学报》
2000年第2期7-9,共3页
Journal of Shanxi College of Traditional Chinese Medicine
关键词
夏枯草醇提物
糖尿病
肾脏病变
醛糖还原酶
alcohol extract of spica prunellae(AEP)
diabetic
nephropathy
aldose reductase
