摘要
前药具有改变药物的理化性质 ,提高生物利用度 ,增加水溶性 ,减少不良反应 ,定位到达靶器官等特性。前药保持或增强原药的药效 ,同时又克服了原药的缺点。本文主要综合前药原理在新药设计中的典型实例 。
The prodrugs can change the physico-chemical property of drugs,increase bioavailability,enhance water-solubility,reduce side effects or attach to the target.The prodrugs can retain or improve effects of the parent drug,meanwhile,overcome the drawback of the parent drug.The paper introduced and exemplified the principle of the prodrugs used as a method in new drug design.
出处
《齐鲁药事》
2005年第2期99-104,共6页
qilu pharmaceutical affairs
关键词
前药
前药原理
新药研究
靶向药物
生物利用度
prodrugs
principle of prodrugs
new drug design
targeting drugs
bioavailability
