摘要
12名女性健康志愿者按随机交叉试验设计、分3期先后单次口服不同来源的3种米非司酮产品,其中法国产 Ru486片剂作标准参比制剂。用高效液相色谱法测定给药后120 h内的米非司酮血浆浓度。口服 200 mg 后国产全合成米非司酮、国产半合成米非司酮及法国产 Ru486 片剂的药代动力学参数以及两种国产品的生物利用度十分相似,无显著性差异。
The relative bioavailabilily of two Chinese tablets (products made by total synthesis or by semi-synthesis) and French RU486 pills administered orally was investigated in a randomized three-period crossover study in 12 healthy female subjects. Plasma concentrations were measured for 120 h after each oral administration of 200 mg mifepristone. by HPLC assay with UV detection methods. There was no significant difference between these preparations in pharmacokinetic parameters including their relative bioavailability.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1993年第6期427-429,共3页
Acta Universitatis Medicinae Tongji
关键词
米非司酮
生物利用度
药代动力学
mifepristone
relative bioavailability
pharmacokinetics
