摘要
目的研究超细粉在仁术健胃颗粒中的应用。方法药材经预处理后,采用TC20超微粉碎机将薏苡仁和炒白术药材粉碎成超细粉,直接入药,制成颗粒剂。结果经扫描电镜、X射线能谱仪检测,二味药材的超细粉粒径均≤5μm,正态分布测定分别为87.93≤20μm和95.08≤20μm。制剂成型好,服用无砂粒感。结论药材超细粉的在仁术健胃颗粒中的应用,是中药颗粒剂制法的创新,节省了辅料,保留了药材的有效成分,有利于制剂的成型,改善颗粒剂的稳定性。
AIM: To study the application of superfine comminution in Renzhujianwei Granule. METHODS: After being pretreated, Rhizoma Altractylodis macroleplea and coix seed were crushed into ultra-fine powder by TC20 medical superfine crusher. Then the ultra-fine powder was made into the granule. RESULTS: Detected by scanning electron microscope and EDS X-ray detector, the mean diameter of the particle was ≤5 μm; The detection of the normal distribution was 87.93%≤20 μm and 95.08%≤20 μm. CONCLUSION: The application of ultra-fine powder in Renzhujianwei Granule develops a new method of producing granule, that can save the pharmaceatic adjuvants and keep the effective components, and is propitious to the molding of the preparation, and also can improve the stability.
出处
《中成药》
CAS
CSCD
北大核心
2005年第1期15-18,共4页
Chinese Traditional Patent Medicine
关键词
超微粉碎
超细粉
仁术健胃颗粒
superfine comminution
ultra-fine powder
Renzhujianwei Granule
