摘要
目的探讨非酒精性脂肪肝 (non alcoholicfattyliver,NAFL)痰瘀证与纤溶状态的关系。方法将符合NAFL诊断的患者辨证分为痰瘀证组 18例与非痰瘀证组 5 2例 ,并设健康人对照组 2 8名 ,比较各组纤溶酶原 (plasminogen ,PLG)、组织纤溶酶原激活物 (tissueplasminogenactivator,t PA)、1型纤溶酶原激活物抑制物 (plasminogenactivatorinhibitor 1,PAI 1)、D 二聚体的变化。 结果NAFL患者t PA活性明显低于健康人对照组 (P <0 0 1) ,PLG、PAI 1活性明显高于健康人对照组 (P <0 0 5 ) ;与非痰瘀证组比较 ,痰瘀证组患者t PA活性明显降低 ,PLG、PAI 1活性明显升高 (P <0 0 1) ,而D 二聚体差异无显著性 (P >0 0 5 )。结论NAFL痰瘀证患者纤溶活性明显降低 ,存在不同程度的微循环障碍或高黏状态 ,采用化痰散瘀治疗有积极意义。
Objective To explore the relationship between phlegmstasis Syndrome (PSS) and the fibrinolytic status in patients with nonalcoholic fatty liver (NAFL). Methods Seventy patients with NAFL were divided into the PSS group and nonPSS group according to TCM Syndrome typing, and a control group consisted of 28 healthy subjects was set up. Levels of plasminogen (PLG), tissue plasminogen activator (tPA), plasminogen activator inhibitor1 (PAI1) and Ddimer were determined and compared. Results The activity of tPA in NAFL patients was significantly lower than that in the control group ( P <005), and PLG and PAI1 were significantly higher than those in the control group ( P <005), and P
LG and PAI1 were significantly higher than those in the control group ( TBX
〗P <005). In respect to the TCM Syndrome typing, in patients of PSS,
tPA was significantly lower and PLG, PAI1 were significantly higher than tho
se in patients of nonPSS ( P <005 or P <00
1), while Ddimer was insignificantly different between patients of the two Syn
drome types ( P >005).
Conclusion NAFL patients of PSS type shows significant l
ower of fibrinolytic activity, indicating that there is certain degree of microc
i
rculatory disturbance and hyper viscosity state, so the application of dissolvi
ng phlegm and dispelling stasis principle in treating NAFL is significant.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第1期22-24,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
瘀证
痰瘀
患者
对照组
纤溶状态
健康人
T-PA
结论
显著性
目的
fatty liver
plasminogen
tissue plasminogen activator
plasminogen activator inhibito-1
D-dimer
phlegmstasis Syndrome
