3Gleason C E, Gonzalez M, Harmon J S, et al. Determinants of glucose toxicity and its reversibility in the pancreatic islet bata-cell line, HIT-T15 [J]. Am J Physiol Endocrinol Metab, 2000,279: E997-E1002.
4Moran A, Zhang H J, Olson L K, et al. Differentiation of glucose toxicity from bata cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15 [J]. J Clin Invest, 1997,99:534-539.
5Kilpatrick E D, Robertson R P. Differentiation between glu cose-induced desensitization of insulin secretion and ββ-cell exhaustion in the HIT-T15 cell line[J]. Diabetes, 1998,47:606-611.
6Bjorklund A, Lansner A, Grill V E. Glucose-induced[Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation [J]. Diabetes, 2000,49: 1840-1848.
7Poltout V, Olson L K, Robertson R P. Chronic exposure of β TC-6 cells to supraphysiologic concentrations of glucose decrease binding of the RIPE3b1 insulin gene transcription activator[J]. J Clin Invest, 1996,4:1041-1046.
8Marshak S, Leibowitz G, Bertuzzi F, et al. Impaired β-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose [J]. Diabetes, 1999, 48:1230-1237.
9Harmon J S, Gleason C E, Tanaka Y, et al. In vivo prevention of hyperglycemia also prevents glucotoxie effects on PDX-1 and insulin gene expression [J] . Diabetes, 1999,48:1995-2000.
10Macfarlane W M, Shepherd R M, Cosgrove K E, et al.Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+[J] . Diabetes, 2000,49: 418-423.
