摘要
目的 探讨肾移植术后早期发生的血管性排斥逆转后对晚期排斥发生的影响。方法回顾性分析自 1988年 5月至 2003年 3月在本中心进行首次单纯尸体肾移植病例 1062例。根据术后1个月内有无发生血管性排斥情况,分为血管性排斥组(45例)与无血管性排斥组(1017例)。随访至少 6个月,比较术后 1月以后两组排斥发生率情况。结果 两组在受体移植时年龄、性别比例、淋巴毒、冷 /热缺血时间、免疫抑制剂方案及随访期间血清肌酐浓度无统计学差异。血管性排斥组排斥逆转后总的排斥发生率为 2 .22% (1 /45), 无血管性排斥组为 12. 59% (128 /1017),两组有显著统计学差异(P=0 .034)。结论 完全逆转的早期血管性排斥可以降低其后排斥的发生率。
Objective To explore the influence of early completely reversal vascular rejection on late rejection Methods The data of 1062 patients who received their first cadaveric transplants between May 1988 and March 2003 were analyzed respectively The patients were divided into 2 groups: group with vascular rejection occurring within 1 month postoperatively ( n =45), and group without vascular rejection ( n =1017) Follow up was performed for at least 6 months The influence of demographic characteristics (transplant age, sex), transplant variables (complement dependent cytotoxity test, cold /warm ischemia time), and post transplant variables ( immunosuppressive agents for the prevention of acute rejection,) were analyzed Results There were no differences in the age at transplantation, sex, complement dependent cytotoxity test, cold/warm ischemia time, immunosuppression agent protocol, and serum creatinine during follow up between the recipients of these two groups Late rejection, including acute interstitial rejection, borderline rejection, and chronic rejection, occurring one month after transplantation was 2 22%(1/45)in the vascular rejection group, significantly lower than that of the no vascular rejection group (12 59%, 128/1017, P =0 034) Conclusion Early completely reversal vascular rejection can reduce the rate of late rejection
出处
《中华医学杂志》
CAS
CSCD
北大核心
2005年第5期332-334,共3页
National Medical Journal of China
