摘要
目的:研究胃小细胞癌(SCCS)的临床病理特征。方法:本文对22例SCCS的病理形态进行观察,14例做NSE、ChromograninA、CEA、Cytokeratin免疫组化染色,6例行电镜观察。结果:SCCS占同期胃癌的2.5％(22/1600例),中、晚期浸润性癌占95.4％,在SCCS分型中复合型12例,纯小细咆癌6例,混合性2例。19/22例有淋巴结转移,占86.7％;侵犯脉管和神经各占10例(45.5％)和5例(22.7％);肝转移相远处淋巴结转移各1例。小细胞成份NSE、Chromogranin A轻至中度表达,腺或鳞癌分化区域CEA、Cytokeratin轻至中度表达,3例电镜下找到神经内分泌颗粒。结论:SCCS同肺小细胞癌一样,是高度恶性的神经内分泌癌,并伴有多向分化的特征,应与胃低分化腺癌区分。
Purpose:To study the clinical pathologic character of small cell carcinoma of the stomach(SCCS). Methods:The pathologic features of 22 cases were observed, 14 of them immunochemically stained with NSE、 Chromogranin A、 CEA and CK.6 of them observed under electron microscope. Results:The SCCS accounted for 2. 5% (22/1600) in the same period patients of carcinoma of the stomach. In 22 cases of SCCS, 21(95. 4%) were advanced type , 12 were combined type, 6 cases were pure small cell, 2 were compound. The number of SCCS metastasizing to lymphonode was 19 (86.7% ) , invading vasculars and nerves were 10(45. 5%) and 5(22. 7%) respectively. One case was found metastasized to liver and one case metastasized to distant lym-phonode. The results of immunohischemistry indicated that NSE and chromogranin A on the small cell areas, CEA and CK on the adennocarcinoma or squamous cancer were weakly to strongly positive. There were neuroendocine particles in the carcinoma cells of 3 cases observed under electron microscopy. Conclusions:The SCCS is a highly malignant neuroendocrine cancer similar to the small cell carcinoma of the lung and multiple differentiated character. This kind of carcinoma should be differentiated with poorly differentiated adeonocarcinoma of the stomach.
出处
《临床肿瘤学杂志》
CAS
1997年第2期4-6,共3页
Chinese Clinical Oncology
