摘要
目的:研究定向毁损伏隔核(nucleusaccumbens, NAc)与腹侧被盖区(ventraltegmentalarea,VTA)对药物诱导 戒断大鼠吗啡觅药行为的影响,分析NAc和VTA在大鼠成瘾 行为中的作用.方法:雄性SD大鼠通过吗啡强化形成条件性 位置偏爱后,使用直流电分别毁损NAc与VTA.15d后给予 sc吗啡诱导大鼠恢复位置偏爱行为,测量并比较毁损组与对 照组的位置偏爱得分.结果:NAc毁损组和与VTA毁损组大 鼠在注射吗啡诱导下未恢复对吗啡的条件性位置偏爱[NAc 毁损组(471±52)s,NAc对照组(673±53)s;VTA毁损组 (482±49)s,VTA对照组(700±46)s].结论:毁损NAc和 VTA能阻断注射吗啡诱导戒断大鼠恢复觅药行为.在成瘾药 物诱导戒断动物觅药行为中,NAc和VTA起重要作用.
AIM: To examine the possible role of nucleus accumbens (NAc) and ventral tegmental area (VTA) in drug priming-induced reactivation of extinguished conditioned place preference (CPP). METHODS: After the rats were successfully trained with morphine (10 mg/kg, sc.) by a CPP paradigm, NAc and VTA were lesioned with a DC current passing through the location. After a 15-day Abstinence period, drug priming (morphine 1 mg/kg, sc.) was given and the place preference score was recorded. RESULTS: Drug priming reactivated the place preference in sham lesion rats. However, the effect of drug priming-induced reactivation of extinguished CPP could be completely abolished by lesion of NAc and VTA. CONCLUSION: These results indicate that NAc and VTA play an important role in drug priming-induced reactivation of extinguished CPP.
出处
《第四军医大学学报》
北大核心
2005年第2期122-124,共3页
Journal of the Fourth Military Medical University
关键词
吗啡
复吸
伏核
腹侧被盖区
条件性位置偏爱
morphine
relapse
nucleus accumbens
ventral tegmental area
conditioned place preference
