摘要
目的 探讨对比增强磁化传递 (magnetisationtransfer,MT)MRI在肺癌脑内小转移灶的应用。方法 对 6 0例病人 (含 172个转移灶 )进行对比增强磁化传递前后的对照研究。对比增强磁化传递前采用SE序列T1WI。然后 ,注射钆喷替酸葡甲胺 (Gd DTPA) (0 1mmol/kg)增强后 ,进行SE序列T1WI和SE序列T1WIMT技术成像。通过比较对比度 /噪声比值 (C/Ns值 ) ,对采用MT技术与否的影像结果进行评估 ;再对采用MT技术与否所显示的转移灶数量进行对照。结果 所有采用T1WI对比增强MT技术的图像C/Ns值比常规T1WI对比增强图像的C/Ns值高。采用MT技术图像的C/Ns值为 2 6 98± 7 0 6 ( x±s) ,常规T1WI对比增强图像的C/Ns值为 15 5 1± 8 5 4 ,t =8 0 2 ,P <0 0 1。T1WI对比增强MT技术比常规T1WI对比增强能显示更多的转移灶数目 (6 0个 ) ,χ2 =7 79,P <0 0 1。结论 在显示肺癌脑内小转移灶方面 ,T1WIMT对比增强比常规T1WI对比增强更为敏感 ,对评估中枢神经系统转移性疾病具有重要的临床价值。
Objective To study the brain small metastatic focus from primary lesion of the lung by means of MR imaging with contrast enhanced magnetization transfer (MT) Methods SE T 1WI was obtained before and after the administration of Gd DTPA (0 1 mmol/kg) with and without MT in 172 lesions of 60 patients Metastatic lesions of the brain were evaluated by means of a contrast to noise ratio(C/Ns) Number of lesions was counted and compared on the two types of images Results All lesions had a higher C/Ns on T 1WI MT images than on conventional images C/Ns was 26 98±7 06 (mean±standard error) for MT and 15 51±8 54 for conventional images ( t =8 02, P <0 01) The SE T 1WI MT images showed significantly more lesions (60 lesions) than the routine SE T 1WI (χ 2=7 79, P <0 01) Conclusion MR imaging performed with MT appears to be more sensitive than routine SE T 1WI in the detection of small lung metastatic lesions in the brain and may become an important clinical technique in the evaluation of metastatic disease of the central nervous system (CNS)
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2004年第12期1252-1255,共4页
Chinese Journal of Radiology
