摘要
目的探讨实验性腹膜炎时,内毒素与肺损伤的变化。方法用酵母多糖A腹腔注射制备大鼠急性实验性腹膜炎模型,随机分为模型组和对照组;观察实验性腹膜炎时,肺损伤变化。结果模型组内毒素、肺匀浆脂质过氧化物,以及白细胞计数均明显增高;而还原谷胱甘肽(GSH)明显降低,与对照组比差异有显著性(P<005)。结论实验性腹膜炎时,内毒素的形成、细菌因子的释放及脂质过化与肺损害有一定的联系。
Objective To explore the effect of endotoxin to lung in experimental peritonitis.Methods Acute peritonitis model was produced by intraperitoneal injection of zmosan A in SD rats,2 days later,the levels of endotoxin and leukocyte in peripheral blood were measured,the levels of lipoperoxides (MDA and SOD) and glutathione (GSH) in lung homogenate were also measured.Results The levels of endotoxin,leukocyte,MDA and SOD were all signifificantly higher than control group,while, the level of glutathione (GSH) was much lower in experimental group (P<0 01).ConclusionEndotoxin and lipoperoxides might play roles in lung damage in experimental peritonitis.
出处
《中国微生态学杂志》
CAS
CSCD
2004年第6期338-339,共2页
Chinese Journal of Microecology
