摘要
目的评价19S-IgM-梅毒螺旋体明胶凝集试验(19S-IgMTPPA)法检测梅毒患者血清中特异性TP-IgM抗体的临床意义。方法采用经IgG/RF免疫吸附剂处理后的93例梅毒患者血清和3例梅毒妇女所生新生儿血清,用TPPA法检测TP-IgM抗体。结果73例未经正规驱梅治疗的梅毒患者血清中,一期梅毒的TP-IgM抗体阳性率78.26%(18/23),二期梅毒的阳性率100%(32/32),隐性梅毒的阳性率47.06%(8/17),3例梅毒妇女所生新生儿血清TP-IgM抗体1例阳性。经正规驱梅治疗RPR转阴的21例梅毒患者血清中TP-IgM抗体阳性率4.76%(1/21)。结论采用19S-IgM-TPPA法检测先天梅毒和二期梅毒具有较高的价值,但不宜单独应用诊断一期和隐性梅毒,对梅毒疗效的观察有待进一步研究。
Objective To evaluate the clinical significance of 19S-IgM-TPPA assay on detection of specific 19S-IgM antibody in syphilitic patients. Methods The serum of 93 syphilitic patients and 3 born infants of syphilitic mothers were treated with IgG/RF immunoabsorbent, then TP-IgM in the serum were detected by TPPA assay. Results In 73 patients who had not been treated regularly, the positive rate is 78.26%(18/23) in primary syphilis,100%(32/32) in secondary syphilis, 47.06%(8/17) in latent syphilis and one case is positive among the three infants. In 21 patients who had been treated regularly, negative in RPR assay the positive rate was 4.76%(1/21). Conclusion There is high value to detect secondary and congenital syphilis with 19S-IgM-TPPA assay, but it is not suitable to diagnose primary and latent syphilis only using 19S-IgM-TPPA assay. The curative effects will be determined by further study.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2004年第4期227-228,共2页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
