摘要
目的 采用两种新的配方制备壳聚糖 海藻酸钠小丸 ,考察小丸干燥方法 (- 5 0℃冷冻真空干燥和 5 0℃烘箱干燥 )对小丸漂浮及药物缓释性能的影响。方法 采用锐孔凝固浴法制备壳聚糖 海藻酸钠小丸 ,体外释药实验考察小丸的漂浮和释药情况。结果 通过改变小丸的配方 ,使烘干小丸在 37℃人工胃液中漂浮率达到 1 0 0 %,雷尼替丁释放时间最长能达到 5h。其漂浮效果与成本较高的冷冻干燥法相当 ,且药物释放时间得到延长。结论 新配方制备小丸在口服胃漂浮释药上有一定应用前景。
OBJECTIVE Ranitidine pellets floating in stomach were prepared with chitosan using sodium alginate as cross-linking agent.The effect of drying methods (freeze dried at -50℃ or oven dried under 50℃ circumstance) on floating and release behavior of prepared pellets were investigated.METHOD Pellets were prepared with the needle dropping method.The sustained release and floating capability of ranitidine pellets were studied in vitro. RESULTS By adjusting the formulation the floating percent of the oven-dried pellets was 100% as the expensive freeze-dried method.And the drug release time from the pellets was extended. CONCLUSION The release profiles showed that the oven-dried pellets could be a potential dosage form for oral sustained delivery in stomach.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2004年第6期475-479,共5页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金 (2 0 2 740 3 8)
关键词
壳聚糖
海藻酸钠
胃漂浮小丸
chitosan
sodium alginate
pellets floating in stomach
