摘要
目的用人肝微粒体研究部分临床常用的药物对西尼地平代谢的影响。方法采用HPLC方法测定西尼地平及其代谢物,色谱柱为HypersilC18柱(250mm×46mmID,5μm),流动相为乙腈甲醇001mol/L四丁基溴化铵溶液(55∶5∶40),柱温50℃,紫外检测波长238nm。结果环孢素、红霉素和辛伐他丁可以较明显地抑制肝微粒体中西尼地平的代谢,而其他药物甲苯磺丁脲、格列齐特、格列喹酮、格列美脲、二甲双胍、卡托普利、法莫替丁对西尼地平的代谢没有明显的影响。结论研究提示环孢素、红霉素和辛伐他丁与西尼地平可能产生代谢相互作用。
AIM:To study the metabolic interaction of cinildipine with some drugs often co-administrated clinically in human liver microsomes. METHOD:Chromatographic analysis was performed on Hypersil BDS C 18 column.The mobile phase consisted of acetonitril-methanol-water containing 0.01mol/L tetrabutyl ammonium bromide(55∶5∶40,v/v/v) and the UV detection wavelength was set at 238 nm.RESULT: Cyclosporin A,erythromycin and simvastatin could significantly inhibit the metabolism of cinildipine in human liver microsomes,while such drugs as tolbutamide,gliclazide,glimepiride,metformine,captopril and famotidine had no significant inhibitory effect on the metabolism of cinildipine.CONCLUSION:The inhibitors or substrate of CYP 3A may affect the metabolism of cinildipine.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2004年第6期524-527,共4页
Journal of China Pharmaceutical University
基金
国家高技术研究发展计划(863计划)资助项目(No.2003AA2Z347A)
江苏省药代动力学重点实验室资助项目(No.BM2001201)~~
