摘要
目的 探讨以腹膜透析为主综合治疗急性重症胰腺炎 (SAP)的疗效。方法 对 18例SAP进行持续性腹膜透析 6～ 10天 ,并规范内科综合治疗方案 ,检测外周血、腹膜透析液中TNF、IL - 6、IL - 8三种细胞因子在治疗前后各时相点的含量 ,并观察血、尿淀粉酶、白细胞计数恢复正常范围时间、平均住院天数、并发症发生率、病死率、治愈率等指标。并与前两年在本院住院病情相同的病例作对照。结果 腹膜透析治疗后血、腹膜灌洗液三种细胞因子第 1、2、3、6天与治疗前比较显著降低 (P <0 .0 1)。治疗组的腹痛、腹胀缓解时间、血、尿淀粉酶、白细胞计数恢复正常值范围时间、平均住院天数 (2 5± 5vs4 5± 8)、并发症的发生率 (2 2 .2 %vs4 5 .5 % )、死亡率 (11.1%vs36 .4 % )均较对照组显著降低 (P <0 .0 1)。结论 早期腹膜透析治疗可清除SAP的细胞因子。同时规范综合治疗方案 ,可以减少并发症的发生 ,改善预后 ,降低病死率。
Objective To investigate the therapeutic effect of peritoneal dialysis for serve acute pancreatitis.(SAP).Methods Peritoneal dialysis was applied for 18 cases SAP for six to ten days. And all SAPs were treated by the standard conventional model of therapy. TNF, IL-6,IL-8 in peripheral blood, dialysis liquid before and after treatment at 1,2,3,6 day were detected. The time of becoming normal of amylase in blood and urine, WBC count, average time of hospital stay, morbidity, mortality, cure rate were observed. Morbidity, mortality, cure rate were compared those with the SAPS who was in hospital two years ago.Results After peritoneal dialysis, the first ,second, third and sixth day TNF, IL-6,IL-8 in blood and washing liquid were statistically reduced than before treatment(P<0.01). Compared to the control group, the release time of abdominal pain, abdominal distension,amylase, WBC count, average time of hospital stay (25±5vs48±8), morbidity(11.1%vs35.4%), mortality(22.2%vs45.5%) in treatment group were statistically reduced.Conclusion Our study results show peritoneal dialysis can clean SAP's TNF, IL-6,IL-8 cell factors in early days. United with standard conventional model of therapy may reduce morbidity and mortality of SAP.
出处
《广西医学》
CAS
2004年第12期1779-1781,共3页
Guangxi Medical Journal
关键词
胰腺炎
急性坏死性
腹膜透析
细胞因子
综合治疗
Pancreatitis
Acute necrotizing
peritoneal dialysis
cell factor
colligation therapy
