摘要
目的 :探讨急性冠脉综合征 (ACS)患者血浆组织因子 (TF)水平及其临床相关性。方法 :采用ELISA法测定急性心肌梗死组 (AMI组 ,2 6例 )、不稳定心绞痛组 (UAP组 ,2 9例 )、稳定心绞痛组 (SAP组 ,2 0例 )和正常对照组 (14例 )的TF水平 ,并观察其与冠脉病变支数、血常规、血脂等生化指标的关系。结果 :AMI组和UAP组血浆中TF含量明显高于SAP组和正常对照组。TF水平与冠脉造影病变支数呈正相关 (r=0 .4 0 4 ,P <0 .0 5 ) ;与载脂蛋白A I(ApoA I)呈负相关 (r=- 0 .4 88,P <0 .0 5 )。结论 :血浆TF在ACS患者升高 ,并与冠脉病变支数和ApoA I相关。
Objective:To investigate the correlation between serum tissue factor (TF) and clinic in acute coronary syndrome.Methods:Levels of serum tissue factor were measured among 26 acute myocardial infarction (AMI), 29 unstable angina pectoris (UAP),20 stable angina pectoris (SAP),and 14 normal healthy control subjects by ELISA. The relationship between TF and clinical examination such as coronary angiography, plasma lipid level and blood routine test were evaluated.Results:TF levels in AMI and UAP group were significantly higher than SAP and the healthy control groups.TF was positively correlated with the sum of stenosed coronary arteries (r=0.404,P<0.05) and negatively correlated with ApoA-I (r=-0.488,P<0.05).Conclusion:The level of TF was elevated in acute coronary syndrome and correlated with the sum of stenosed coronary srteries and ApoA-I.
出处
《天津医药》
CAS
北大核心
2004年第12期731-733,共3页
Tianjin Medical Journal
基金
天津市科委发展计划项目资助课题 (项目编号 :993 112 911)
