摘要
目的 :探讨肺炎衣原体 (Cpn组 )感染与冠心病心肌梗死的关系。方法 :测定 5 1例急性心肌梗死 (AMI)和4 2例陈旧性心肌梗死 (OMI组 )患者及 31例冠脉造影正常者 (NC组 )的血Cpn抗体水平及DNA ,同时观测纤维蛋白原(Fg)、6 -酮 -前列环素F1α (6 Keto PGF1α)及血栓素B2 (TXB2 )变化及其与Cpn感染的相关性。结果 :AMI组CpnIgG、CpnIgM阳性率及水平高于NC组 (P <0 .0 5 ) ,CpnDNA检测结果与之吻合。校正冠心病危险因素前、后 ,CpnIgG阳性与AMI均有相关关系 (OR分别为 3.6 5 3和 3.174 ,P <0 .0 5 )。AMI组中Cpn(+)组Fg、TXB2 高于Cpn(- )组 ,而 6 Ke to PGF1α低于Cpn(- )组 (均P <0 .0 5 )及NC、OMI组中Cpn(+)组 (均P <0 .0 1) ;并且IgG与TXB2 呈正相关 ,与 6 Ke to PGF1α呈负相关 ,调整冠心病的危险因素前、后 ,IgG与Fg均呈正相关。结论 :Cpn感染与AMI有明显的相关性 ,与Fg、TXB2 及 6 Keto
Objective: To investigate the correlation between chlamydia pneumoniae (Cpn) infection and acute myocardial infarction (AMI). Methods: Specific Cpn antibodies and the DNA were measured in 51 patients with AMI (AMI group), 42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group) who had no angiographic evidence of coronary artery disease. The changes of and the relationships between fibrinogen (Fg), 6-Keto-prostaglandin-F1α (6-Keto-PGF1α), Thromboxane B 2(TXB 2), and Cpn infection were observed in the three groups. Results: The positive rate and level of Cpn IgG and Cpn IgM in group AMI were higher than those in group NC (P<0.05). So was the detective result of Cpn DNA. The correction of coronary heart disease risk factors and the positive of Cpn IgG were correlated with AMI (OR?3.653, P<0.05; OR?3.174, P<0.05). The levels of Fg and TXB 2 of those who were Cpn positive in AMI group were significantly higher and the level of 6-Keto-PGF1α of those who were Cpn positive in AMI group was significantly lower not only than those who were Cpn negative (P<0.05) in the same group but also than those who were Cpn positive in the NC group and OMI group (P<0.01). The average concentration of IgG antibody to Cpn was positively associated with the levels of Fg and TXB 2 but negatively associated with the level of 6-Keto-PGF1α in the Cpn positive patients of the AMI group. Conclusion: There is a significant correlation between Cpn infection and AMI. Cpn infection is associated with Fg, TXB 2 and 6-Keto-PGF1α.
出处
《天津医药》
CAS
北大核心
2004年第12期724-727,共4页
Tianjin Medical Journal
基金
贵州省科学基金资助项目 (黔科合字 19991177号)
