摘要
目的 探讨产超广谱β 内酰胺酶 (ESBLs)肠杆菌科细菌的医院感染和耐药现状。方法 采用双纸片协同试验及纸片确证试验检测医院感染病例中产ESBLs菌 ,采用纸片扩散法测定产ESBLs菌和不产ESBLs菌的耐药率并加以比较。结果 12 5株肠杆菌科细菌检出产ESBLs菌共 4 1株 ,产酶率为 32 .8% ,产酶株均为大肠埃希菌(16株 )和肺炎克雷伯菌 (2 5株 ) ,耐药表型结果显示产ESBLs菌对抗生素耐药率明显高于非产ESBLs菌。结论 产ESBLs是肠杆菌科细菌对 β 内酰胺类抗生素耐药的重要机制 。
OBJECTIVE To investigate the existence of nosocomial infections caused by β lactamases (ESBLs) producing Enterobacteriaceae. METHODS ESBLs were detected by double synergy test and disk confirmatory test. Disk diffusion test was used for antimicrobial susceptibility and comparisons of the susceptibility rates were drew between the ESBLs producers and nonproducers. RESULTS ESBLs producers were 41 among the total 125 Enterobacteriaceae strains, the percentage was 32.8%. From them there were 16 Escherichia coli strains, and 25 Klebsiella pneumoniae strains. The rate of drug resistance of the ESBLs producers was higher than that of nonproducers. CONCLUSIONS ESBLs are the most important resistant mechanisms of Enterobacteriaceae to antibiotics. It is necessary to detect and control the ESBLs producers standardly for clinical microbiology department.
出处
《中华医院感染学杂志》
CAS
CSCD
2004年第6期684-685,共2页
Chinese Journal of Nosocomiology
关键词
超广谱Β-内酰胺酶
肠杆菌科细菌
医院感染
耐药表型
Extended-spectrum β-lactamases
Enterobacteriaceae
Nosocomial infections
Resistant phenotype
