摘要
目的 探讨不同配伍比例的芍药甘草汤治疗原发性痛经镇痛作用机制。方法 采用催产素所致大鼠子宫剧烈收缩作为痛经症模型,以阿司匹林作对照,分别测定子宫内皮素(ET-1)和一氧化氮(NO)的变化。结果 芍药甘草汤不同配伍比例能明显抑制催产素诱发大鼠扭体反应次数(P<0.01),具有镇痛作用;模型组大鼠子宫NO的含量降低。与正常组比较差异显著(P<0.01);经芍药甘草汤不同配伍比例治疗后,子宫组织ET-1含量降低,而NO含量有所升高,与模型组比较差异显著(P<0.01);芍药甘草汤不同配伍比例治疗中,3∶1组与1∶1、2∶1、阿司匹林组比较差异显著(P<0.01)。结论 提示芍药甘草汤能对抗催产素所致的大鼠扭体反应,其临床治疗痛经症的作用可能与调节子宫组织中ET-1、NO活性有关,且芍药与甘草比例为3∶1时镇痛作用可能较佳。
Objective To investigate the effect of the different compatibilities of Shaoyaogancaotang (SYGCT) of threating primary dysmenorrhea. Method Using pitocin to cause rat抯 uterus intense shrinking as the dysmenorrheal animal model, individually testing the changes of ET-1 and NO after treated with the different compatibilities of SYGCT. In the same time compared with Aspirin. Result The different compatibilities of SYGCT can obviously reduce the writhing times of the model rats caused by pictocin (P<0.01), so it shows the analgesic effect. The model group shows low level of NO in uterus compared with the normal group (P<0.01), after treatment by different compatibilities of SYGCT, the ET-1 of uterus reducing, but the NO slightly rising in the treating group, compared with the model group (P<0.01). In the treatment of using different compatibilities of SYGCT, the 3∶1 group has significant diffrence compared with the 1∶1, the 2∶1 and the Aspirin group (P<0.01). Conclusion The effect of SYGCT treating primary dysmenorrhea is maybe related with regulating the level of ET-1 and NO of the uterus. Among the different compatibilities of SYGCT, the 3∶1 group is better.
出处
《中国中医药信息杂志》
CAS
CSCD
2004年第11期973-974,共2页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
痛经
芍药甘草汤
方剂配伍
内皮素
一氧化氮
大鼠
dysmenorrheal
Shaoyaogancaotang
compatibility of formula
endothelin
nitrogen
