摘要
于25℃,30℃,37℃温度下考察氨甲苯酸、酚磺乙胺与维生素C注射液在生理盐水、5%葡萄糖和5%葡萄糖氯化钠大容量注射液中配伍的稳定性。方法:配伍后采用高效液相色谱法测定氨甲苯酸和酚磺乙胺的含量变化,以氧化还原法测定维生素C的含量变化同时观察配伍溶液的外观及pH值变化。结果:3种药物在3种大容量注射液中配伍后,0～4h内,外观、pH及含量基本稳定。结论:氨甲苯酸、酚磺乙胺与维生素C配伍后4h内可以使用。
Objective:To study on the compatible stability of aminomethylbenzoic acid,etamsylate and vitamin C in injection NS,5%GS and 5%GNS.Methods:HPLC was designed to study the change of content of aminomethylbenzoic acid and etamsylate,and oxidation-reduction titration was used to determine the content of vitamin C after compatibility.Results:There was no evident variation in content,appearance and pH after compatiblity during 4 hours in 25℃,30℃,37℃.Conclusion:During 4 hours the compatibility of aminomethylbenzoic acid,etamsylate and vitamin C is stable,the three drugs can be compatible in clinic.
出处
《中国药业》
CAS
2004年第11期32-33,共2页
China Pharmaceuticals
